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David Shaw of D. E. Shaw Research presents Anton, a special-purpose machine that speeds up biomolecular simulations about a hundred-fold. The lecture covers molecular dynamics and how simulation helps understand how drugs bind.

Douglas Hofstadter lectures at Uppsala University on how analogy and daring thinking drove Einstein's discovery of light quanta. He argues deep insight in physics comes from imaginative leaps rather than rigid logic.

Synthetic organic chemist James Tour gives a lecture arguing that origin-of-life research is far from explaining how life began. The talk was published by the Discovery Institute and drew sharp criticism.

Y Combinator CEO Michael Seibel lectures at Startup School on building a product people want: identifying the problem, the customer, an MVP and which customers to pursue first.

Patrick Winston's long-running MIT lecture on public speaking teaches heuristic rules for talks. It covers how to start, use time and place, boards, props and slides, and how to inform, persuade and finish.

Stanford professor Robert Sapolsky lectures on depression as a real biological disease. He covers its biological and psychological causes, how it differs from ordinary sadness, and ideas such as learned helplessness. He ties these together into one account.

The first lecture of Gilbert Strang's MIT 18.06 Linear Algebra course, covering the geometry of linear equations. It opens a full 35-lecture university course.

Dr. Russell Barkley gives a nearly three-hour lecture of essential ideas about ADHD for parents, covering what ADHD is, its effects on executive function, motivation and emotion, and how it affects children.

Andrej Karpathy's three-hour-plus general-audience deep dive into how ChatGPT-style LLMs are built, covering the full training stack from pretraining to post-training. It also gives mental models for their quirks, like hallucination, and how to use them well.

Psychology professor Marty Lobdell gives a one-hour lecture on how to study effectively, covering short focused sessions with breaks, study environment, note-taking and memory techniques. It was aimed at students who cram without improving.

The first lecture in Bartosz Milewski's category theory series for programmers. It covers the motivation and philosophy behind category theory and why composition matters for handling complexity.

A lecture from MIT's Missing Semester course covering version control with git. It builds up git from its data model rather than from commands.

Dr. Roger Seheult of MedCram reviews the benefits of sunlight beyond vitamin D, covering the solar spectrum, circadian rhythm, melatonin and infrared light. The lecture runs nearly two hours with timestamps.

James Mickens of Harvard gives a funny lecture at HBS's Future Assembly arguing that blockchains are a very bad idea. He covers their trust, legal and practical shortcomings for real-world problems.

Lawrence Krauss's 2009 talk on the current picture of the universe, how it will end and how it could have come from nothing. It covers the expanding universe, cosmic background radiation and the cosmological constant.

A lecture by Richard Feynman on how computers work, using the analogy of a filing clerk that becomes progressively dumber and faster. It also covers heuristics and how computers handle data and solve problems in finite time.

The first lecture of Andy Pavlo's CMU 15-445 Intro to Database Systems (Fall 2019), covering course introduction and the relational model.

Historian and journalist Gwynne Dyer gives a long UBC talk on how climate change will reshape international politics. He covers food, borders, refugees and the possibility of unilateral geoengineering by affected nations.

David Tong, a Cambridge theoretical physicist, explains at the Royal Institution that the fundamental building blocks of nature are quantum fields rather than particles. He covers what we know about these fields and how they fit into the Standard Model.

Alan Kay's Stanford Startup School lecture covers his career at Xerox PARC and how to think about inventing the future. He goes through what came out of PARC and why companies fail to capitalize on such ideas.

Stanford physicist Leonard Susskind explains what the Higgs mechanism is and what it means to give mass to particles. He also covers what is at stake for physics and cosmology.

Cardiologist Dr. Pradip Jamnadas lectures on the rationale for dietary restriction and fasting, covering insulin resistance, glucose intolerance, and low-carb eating over about 81 minutes.

Jack Szostak's lecture covers how cellular life could have arisen from chemistry on the early Earth, starting from the odds of life elsewhere in the galaxy. It is part of a series on protocells and the RNA world.

Chris Granger, creator of Light Table and the Eve language, gives a Berkeley data science lecture on what computation and programming might look like in ten years. He covers the path that led to Eve and ends with demos.

Floyd Toole's CIRMMT distinguished lecture on the science of sound reproduction, drawing on decades of blind listening research. It covers what listeners prefer in loudspeakers and why measured accuracy and anechoic response matter.

Peter Thiel's lecture from the How to Start a Startup course on business strategy and monopoly theory, arguing that competition destroys profits and that startups should aim to build monopolies. It covers the ideas of Zero to One.

Gabriel Lebec's Fullstack Academy talk introduces lambda calculus syntax, the history of mathematical logic, and the essence of functional programming using JavaScript. It also covers combinators, currying and Church encodings.

The opening lecture of MIT 6.824 Distributed Systems (Spring 2020), introducing the course and core challenges of distributed systems. It begins a playlist that goes on to cover Raft and other consensus papers in Go.

Carnegie Mellon professor Randy Pausch gives a lecture on time management at the University of Virginia in 2007. He covers practical habits such as tackling important tasks first and distinguishing important from urgent work.

Simon Peyton Jones gives Churchill College's annual computer science lecture on Haskell's birth and evolution. He covers the most influential ideas, from laziness to monads and type system evolution, plus current developments and guesses about the future.

Andrej Karpathy builds the GPT tokenizer from scratch, implementing byte pair encoding along with encode and decode. He shows how many odd LLM behaviors trace back to tokenization, and covers Unicode byte encodings along the way.

The opening lecture of Steve Brunton's Control Bootcamp, covering the kinds of control and why closed-loop feedback matters. It starts a series that follows the control chapter of the Brunton and Kutz data-driven science book.

The first lecture in an 18-part series on digital photography from Marc Levoy's Stanford CS 178 course, recorded at Google in 2016. The series covers how digital cameras work and computational photography, with slides and assignments available on the course site.

Sean Carroll gives a Royal Institution talk tracing the history of quantum mechanics from Einstein and Bohr to today. He covers the Copenhagen interpretation and the many worlds interpretation.

Michael Sugrue's lecture on Marcus Aurelius' Meditations and the Stoic ideal, covering the text and its philosophy. It is one of his humanities lectures known for their clarity.

The final lecture of Richard Hamming's Learning to Learn course, from 1995, based on his well-known talk 'You and Your Research'. It covers how to do important work and build a career.

The first lecture of Francis Su's Harvey Mudd real analysis course, covering the construction of the rational numbers. It begins a full lecture series that follows a standard analysis text.

An RSA Animate in which Steven Pinker explains how the mind builds infinite meanings from finite language, and why people often speak indirectly. It covers ambiguity, politeness and mutual knowledge, including the emperor's new clothes example.

John Ousterhout lectures on the Raft consensus algorithm, made for the Raft user study comparing how students learn Raft and Paxos. It covers leader election and log repair.

Jeff Dean of Google describes his experiences building Google's systems and how its infrastructure evolved over time. The Stanford talk covers search, scaling tipping points and lessons from building large-scale software.