dna

Destin of Smarter Every Day goes behind the scenes at the 23andMe lab to show how genotyping works. He also discusses DNA testing and privacy.

A compilation of molecular animations of DNA replication and gene transcription by Drew Berry and Etsuko Uno at WEHI, made with no narration. It shows molecular machinery at work inside cells.

Dwarkesh Patel interviews ancient-DNA geneticist David Reich about human prehistory, including the small group that left Africa around 70,000 years ago and the Yamnaya expansion.

Veritasium explains how investigators caught the Golden State Killer using forensic genealogy, matching crime scene DNA to distant relatives in public genealogy databases. It also covers the privacy implications of DNA databases.

John Sotos, a physician and former Intel chief medical officer, argues at DEF CON 25 that genetic diseases are exploitable vulnerabilities in the genome. He warns that CRISPR and related tools will make malicious genome hacks and targeted bioweapons feasible.

Illumina's 3D animation of its sequencing-by-synthesis workflow, from sample preparation and cluster generation to sequencing on a flow cell and data analysis.

A short animation from the DNA Learning Center showing how mRNA carries a gene's message to the ribosome, where tRNA and codons are used to assemble amino acids into a protein.

The Thought Emporium's host describes making and taking a DIY gene therapy to treat his own lactose intolerance. It uses an AAV virus to deliver DNA coding for the lactose-digesting enzyme, made with biohacker Gabriel Licina's help.

A Capella Science parody of Despacito that sings through evolutionary developmental biology, explaining how a single cell becomes a body, including body-axis genes and dormant snake leg DNA. It runs about four minutes.

The Thought Emporium shows how easily bacteria can be genetically modified to produce fluorescent proteins and even bioluminesce, with techniques doable at home. It links to companion videos on incubators, DNA extraction and gels.

Drew Berry shows scientifically accurate animations of molecular processes inside cells, such as DNA replication, at TEDxSydney.

Veritasium explores the Prisoner's Dilemma and Axelrod's tournaments, showing why tit-for-tat and forgiving strategies win in repeated games. It extends the ideas to cooperation in evolution and conflict.

Biologist Michael Levin explains the bioelectric layer that coordinates cells to build organs and bodies, showing footage of two-headed worms and introducing xenobots. He discusses implications for medicine and the nature of life.

A clip from Attenborough's Life of Mammals following a San tribesman in the Kalahari on an eight-hour persistence hunt, running down a kudu through harsh heat. It shows tracking, endurance running and the hunter's reaction after the kill.

Jack Szostak's lecture covers how cellular life could have arisen from chemistry on the early Earth, starting from the odds of life elsewhere in the galaxy. It is part of a series on protocells and the RNA world.

A long Portal podcast episode in which Bret Weinstein tells Eric Weinstein the story of his lab mice telomere work, the prediction behind it, and what it means for science and aging.

A two-minute time-lapse from the Kishony Lab showing bacteria spreading across a giant petri dish with increasing antibiotic doses, evolving resistance as they go.

Kurzgesagt's hour-long animated film that compresses Earth's 4.5 billion year history into one hour, roughly a million years per second. It follows the evolution of life through to humanity's tiny final stretch.

Shaun's roughly 2.7-hour video essay on The Bell Curve. It covers intelligence, the g factor, IQ tests, IQ versus environment and the politics behind the book, with a critical reading of the sources.

An excerpt of the 2005 Harvard debate in which Steven Pinker gives his prepared case on biological sex differences and the under-representation of women in science. It covers cross-cultural patterns in preferences and abilities and the overlap between male and female distributions.

Daniel Dennett's Royal Institution lecture on whether the brain is a computer and where its software comes from. He argues that minds are built by evolution and culture, with competence arising without comprehension.

Clinical psychologist Stephen Ilardi argues depression is a disease of modern civilization and presents a lifestyle-based program to treat it without drugs. Topics include exercise, sunlight, omega-3s and social connection.

Stanford biologist Robert Sapolsky lectures on the evolution of behavior, including the Prisoner's Dilemma and tit-for-tat strategies in animals. It is part of his Human Behavioral Biology course.

David Epstein argues in this TED talk that improving athletic records owe much to technology, training and the selection of specialized body types, not just humans getting inherently better. He gives counter-intuitive examples across sports.

Daniel Dennett gives a Royal Institution talk toward a unified theory of information, tying together evolution, learning and engineering. He argues that design can arise bottom-up through small steps without a designer.

Michael Levin presents his lab's work on how cellular collectives use bioelectric networks to make anatomical decisions. Topics include pattern memories, regeneration and synthetic living organisms.

Primer simulates green beard altruism, where individuals recognize and help others carrying a shared marker, and shows how imposters affect its evolution. It is an animated evolution simulation based on published papers.

Cognitive scientist Donald Hoffman argues in this TED talk that evolution shaped perception to track fitness rather than truth. He uses evolutionary simulations and the Australian jewel beetle as examples.

A Royal Institution lecture in which Nicholas Humphrey presents his theory of phenomenal consciousness and its evolution. He draws on the book Sentience and discusses evidence for animal sentience.

CGP Grey explains why horses could be ridden and why other animals like zebras and bears were never domesticated for war or riding. It is a follow-up on the topic of animal domestication.

Synthetic organic chemist James Tour gives a lecture arguing that origin-of-life research is far from explaining how life began. The talk was published by the Discovery Institute and drew sharp criticism.

Veritasium explains X-chromosome inactivation, where different cells in a woman's body switch off different X chromosomes, giving a mosaic pattern. It uses animation from the WEHI institute and connects to calico cat coloring.

First episode of the Norwegian documentary series Hjernevask, in which Harald Eia interviews researchers on the nature versus nurture debate. It focuses on the gender equality paradox and gender differences in career choice.

Kurzgesagt's animated explainer on CRISPR gene editing, covering how the technology works and what it could mean for curing disease, designer babies and aging. It frames genetic engineering as an irreversible change coming to humanity.

Steve Hsu's 2011 Google Tech Talk reviews psychometric measurement of intelligence and the heritability of adult IQ, then discusses genome-wide association studies seeking the genes behind cognitive ability.

Curious Droid asks what traces human civilization would leave in the geological record 65 million years from now. It considers how thin the fossil record of humanity might be.

Harvard geneticist David Sinclair discusses his book Lifespan at Google. He covers the biology of aging, lifestyle interventions and possible future ways to slow or reverse it.

Karl Sims's 1994 demonstration of evolved virtual creatures: block-bodied creatures whose bodies and controllers are evolved through selection, mutation and recombination to swim, walk and compete.

Stated Clearly explains the RNA world hypothesis, which resolves the chicken-or-egg problem of genes versus enzymes by proposing that RNA once did both jobs. It outlines how evolution could begin with RNA chains alone.

An excerpt from Richard Dawkins's lecture on Climbing Mount Improbable demonstrating how a complex eye can evolve through incremental steps. It answers the creationist irreducible complexity argument.