gene therapy

The Thought Emporium's update on the home-brewed gene therapy he took to cure his lactose intolerance. It reports how the effect held up over two years and what future versions might look like.

ScienceClic explains why the rubber sheet analogy for general relativity is misleading and offers a new visualization that includes the curvature of time and shows gravity as motion through curved spacetime.

Kurzgesagt's animated explainer on CRISPR gene editing, covering how the technology works and what it could mean for curing disease, designer babies and aging. It frames genetic engineering as an irreversible change coming to humanity.

A Kurzgesagt animation on using gene drives to modify mosquitoes against malaria, and whether we should. It explains the mechanism and the ethical trade-offs.

Veritasium explains how investigators caught the Golden State Killer using forensic genealogy, matching crime scene DNA to distant relatives in public genealogy databases. It also covers the privacy implications of DNA databases.

An animated Kurzgesagt explainer on bacteriophages, viruses that kill bacteria, covering how they infect and burst cells and their potential as therapy against antibiotic-resistant bacteria.

A Computerphile video in which Rob Miles warns against assuming a general AI will think like a human. He uses the thought experiment of a stamp-collecting AI to show how a goal-driven system could pursue its aim with dangerous results.

Alex O'Connor shows that ChatGPT cannot draw a wine glass filled to the brim, and ties the failure to David Hume's missing shade of blue. It asks what the failure says about how image models learn.

Dr Mike Pound explains the suspected backdoor in the Dual_EC_DRBG random number generator and how elliptic curve constants could let someone predict its output.

3Blue1Brown shows how the uncertainty principle arises from Fourier transforms. A wave packet cannot be narrow in both position and frequency, so the principle is a property of waves rather than of measurement.

Veritasium explains, with expert input, that in general relativity gravity is not a force and objects follow straight paths through curved spacetime, including why standing on the ground means you are accelerating.

Martin Donald explains the Wave Function Collapse algorithm using Sudoku-like constraint solving and shows how he implemented it with Blender and Godot. It links demos and reference articles.

Veritasium explores why energy is not conserved in general relativity, using Emmy Noether's theorem linking symmetries to conservation laws. Physicists interviewed explain energy loss in an expanding universe.

AVweb's Paul Bertorelli explains why general aviation has failed to replace leaded avgas, blaming industry inertia, bureaucratic delay and an exemption that removes the incentive. This is part one of two.

AVweb's Paul Bertorelli explains in part two of a series why general aviation has not replaced leaded avgas. He covers industry inertia, bureaucratic delays and the exemption that lets the industry keep using lead.

Stated Clearly explains the RNA world hypothesis, which resolves the chicken-or-egg problem of genes versus enzymes by proposing that RNA once did both jobs. It outlines how evolution could begin with RNA chains alone.

PBS Space Time explores whether time causes gravity, explaining that gravity does not truly warp the flow of time but arises from time gradients. It revisits how gravitational time dilation works in general relativity.

A short animated explainer that stages a $100 footrace in which contestants start at different distances from the line, depending on the advantages or disadvantages they inherited. It uses the race as a metaphor for how unequal starting points shape outcomes, citing US census income and poverty figures.

Musician Benn Jordan uses AI to detect AI-generated music and digs into music industry data, including streaming payouts and sample library copyright problems. He covers ways to tell whether a track is human-made.

Veritasium explores what general relativity says about black holes, white holes and wormholes, with help from physicists Geraint Lewis and Juan Maldacena. It introduces Penrose diagrams and the idea that other universes may be implied.

Vsauce looks at 'juvenoia', the exaggerated fear that new media and youth culture are corrupting the young. It gives historical examples of older generations complaining about the next one.

Veritasium presents David Sinclair's information theory of aging, which says aging is a loss of epigenetic information, and the evidence that aging can be slowed or reversed. It touches on stressors like fasting, exercise and cold exposure.

PBS Space Time explains how general relativity permits warp drive in principle and covers recent theoretical advances toward solving the negative energy problem.

A PBS Space Time episode explaining how space and time swap roles inside a black hole's event horizon. It is part of the channel's black hole series.

PBS Space Time introduces Miguel Alcubierre's warp drive, explaining how spacetime itself could be warped rather than moving a ship through it, and whether it is physically possible.

PBS Space Time explains what happens as you approach and cross a black hole's event horizon, using Penrose diagrams and light cones as the tool for understanding spacetime there.

A PBS Space Time episode asking what black holes really are and whether events can happen inside them. It covers event horizons, time dilation and common misconceptions about black holes.

Veritasium explains X-chromosome inactivation, where different cells in a woman's body switch off different X chromosomes, giving a mosaic pattern. It uses animation from the WEHI institute and connects to calico cat coloring.

A short Coding Secrets episode explaining why hitting a Sonic 3D cartridge triggers a hidden level select. The cause was a custom crash handler that redirected CPU error interrupts to the level select screen.

A Wendover Productions video on how dollar store chains expanded across America and why they displace grocery stores in small towns. It covers their business model and supplier leverage.

AVweb's Paul Bertorelli analyzes the safety record of the Cirrus Airframe Parachute System (CAPS), looking at the 90-plus deployments over 20 years of Cirrus flying. He asks whether the whole-aircraft parachute has actually saved lives.

ScienceClic visualizes what you would see falling into a black hole, from the approach and the accretion disc to crossing the horizon, in 15 minutes.

A PBS Space Time episode on how gravitational wave observations of a neutron star merger, GW170817, can limit the number of spacetime dimensions. It is based on a 2018 paper.

Computerphile video in which Mike Pound explains a University of Maryland paper on watermarking LLM output. The method biases token choices so generated text can later be detected statistically.

A guest video by Welch Labs on 3Blue1Brown explaining how text-to-image and video models work. It covers CLIP, shared embedding spaces, diffusion models (DDPM, DDIM), conditioning, guidance and negative prompts.

A PBS Space Time episode asking whether our universe could sit inside a black hole. It covers what physicists think happens inside black holes and the arguments for and against this idea.

Robert Miles covers a paper where researchers ran real versions of his earlier mesa-optimizer thought experiments. They show inner misalignment, where an AI learns the wrong goal in training and misbehaves when deployed.

Not Just Bikes explains the Strong Towns argument that car-dependent American suburbs cost more to maintain than they generate in taxes. It describes the growth Ponzi scheme that props up municipal finances.

Asianometry explains the EUV light source inside ASML's lithography machines, where lasers hit falling tin droplets twice to produce 13.5 nm light. It walks through the engineering of the droplet generator, the pre-pulse and main laser, and the plasma that results.

An animated introduction to geometric algebra, presented as a language that can describe most of physics. It was made with manim and covers multivectors and how they generalize familiar tools like cross products and quaternions.