immune system

A Kurzgesagt animation of how the immune system responds to a bacterial infection, depicting immune cells as an army defending the body.

A Kurzgesagt animation giving a big-picture tour of the human immune system, its organs, transport network, and the cells it produces every day. It accompanies their IMMUNE book.

A clip from George Carlin's "You Are All Diseased" special in which he riffs on germs, the immune system and white blood cells. It argues that modern obsession with cleanliness is misplaced.

A Kurzgesagt animation about how the immune system constantly detects and kills cells that are turning cancerous. It explains what cancer cells are and why stopping them is so hard.

Kurzgesagt's animated explainer on the human immune system, describing the body as an ecosystem and how immune defenses cope with the variety of invaders. It promotes their book Immune.

FreeBSD developer Benno Rice traces the history of init and bootstrap systems at linux.conf.au 2019 to explain why systemd was seen as necessary and why it provokes such strong reactions. He also discusses why change is scary.

Rich Hickey's 2013 talk applies language-design thinking to whole systems, covering names, queues, data, failure, and the interfaces between programs. It ends with a call to action for building systems holistically.

Jeff Dean of Google describes his experiences building Google's systems and how its infrastructure evolved over time. The Stanford talk covers search, scaling tipping points and lessons from building large-scale software.

Benno Rice's BSDCan 2018 talk on why systemd exists and what it got right and wrong. It traces the history of Unix init and why Linux distributions adopted it, while asking what the BSDs should learn.

José Valim's ElixirConf US 2023 closing keynote on the foundations of the Elixir type system, covering set-theoretic types and gradual typing with strong arrows.

A 1990 lecture by James Gosling on NeWS, Sun's networked window system in which clients send PostScript programs to the server for execution. It covers the high-level imaging model and compares NeWS with similar systems.

Bryan Cantrill's QCon SF 2019 talk asking whether operating systems should be rewritten in Rust. He draws on his systems experience to discuss C, memory safety and Rust's fit for system software.

An AWS re:Invent 2014 talk on the core distributed systems primitives behind AWS and Amazon.com, such as consensus, key-value stores and transactional logging. It describes how AWS builds large services from a few common building blocks.

A short film in which friends build the first true-to-scale model of the solar system, with full planetary orbits, on a Nevada dry lakebed. It conveys the real distances and sizes involved.

Chris Houser's Clojure/conj talk on why Clojure's exceptions destroy information as the stack unwinds, unlike Common Lisp's condition system, which can resume from the error site. He surveys the existing libraries that approximate conditions, explains why they don't compose with each other, and considers what a better design would look like.

A panel from the Lang NEXT 2014 conference on systems programming in 2014 and beyond. Language designers including Bjarne Stroustrup and Rob Pike discuss the topic, including C++ header compile times.

Timothy Roscoe of ETH Zurich delivers the joint USENIX ATC/OSDI 2021 keynote arguing that operating systems must reckon with modern hardware, which is a heterogeneous collection of processors, firmware and coprocessors rather than a simple machine. It shows how much runs below and beside Linux.

The first lecture in Martin Kleppmann's 8-lecture distributed systems series from the University of Cambridge undergraduate course. It introduces the subject, and accompanying lecture notes are available.

Jeff Bonwick and Bill Moore, the creators of ZFS, present 'ZFS: The Last Word in File Systems' at the 2008 SNIA Software Developers' Conference. They explain the design, including copy-on-write, checksumming and avoiding the write hole.

Aditya Siram introduces ATS, a statically typed ML-like language that compiles to C and offers type-safe pointer arithmetic and a full proof language. The Strange Loop talk shows off C interop, concurrency and verification features with non-trivial examples.

Aaron Hsu's FnConf18 talk asks whether APL needs a static type system. He argues that APL's expressiveness and rapid iteration already deliver the benefits usually credited to types.

Joe Duffy's RustConf 2017 closing keynote on his experience at Microsoft building Midori, an operating system written in a Rust-like safe systems language. He covers the technical and cultural challenges of applying those lessons to Windows.

A Microsoft Research talk on BetrFS, a file system built on B-epsilon trees, a write-optimized data structure. It covers WODS such as LSM-trees, how to design a file system around them, and benchmark wins over ext4 and xfs.

Marshall Kirk McKusick gives a talk at EuroBSDCon tracing filesystem and storage development from 1979 to today, using the BSD Fast Filesystem as the focus. It covers early disk-geometry optimization through later contiguous layout and small-file performance work.

A very short microscope clip of a neutrophil chasing a Staphylococcus aureus bacterium, originally from David Rogers at Vanderbilt University. It is a widely reposted piece of immune-system footage.

An animation presenting a non-standard helical or vortex model of the solar system, in which the planets trail the Sun through space instead of orbiting in flat circles. The model is a non-conventional view that the author says differs from standard diagrams.

Richard Cook's short Velocity 2013 talk on resilience in complex adaptive systems, arguing systems operate near the edge of failure and that the surprise is how rarely they fail. He presents a model of how pressures push systems toward failure boundaries.

CGP Grey explains Mixed-Member Proportional representation, the system used in New Zealand where voters get two votes. It covers how it differs from first-past-the-post.

Dr. Richard Cook, a physician and patient safety researcher, presents his ideas on how complex systems fail, at Velocity 2012. He argues for designing for resiliency rather than trying to exhaustively handle every failure mode.

A short edited excerpt of Terence McKenna arguing that culture acts as an operating system for the mind, set to imagery and music. It touches on psychedelics and how they change thinking.

A minutephysics explainer on why the planets orbit in a flat plane. It shows how conserved angular momentum flattens a collapsing cloud of matter into a disk.

Dave Chinner's linux.conf.au 2012 talk on XFS scalability, covering pain points with large numbers of files and complex metadata, and the work to fix XFS metadata performance.

Primer uses simulations to compare voting systems such as first-past-the-post, approval, ranked choice and others. It shows how each system behaves and can be manipulated, with links to further voting theory resources.

Will Wilson of FoundationDB explains how the team tested their distributed database using deterministic simulation. By running the whole system in a simulator with injected faults and reproducible seeds, they could find rare concurrency and network bugs.

CGP Grey explains first-past-the-post voting and why it pushes elections toward two dominant parties. It is the first in his series on electoral systems.

The first lecture of Andy Pavlo's CMU 15-445 Intro to Database Systems (Fall 2019), covering course introduction and the relational model.

CGP Grey explains the Single Transferable Vote, a proportional ranked-ballot system, and why politicians have little incentive to adopt it. It is a short animated explainer of how multi-winner ranked voting works.

Joran Dirk Greef's Systems Distributed '23 talk on TigerStyle, the engineering methodology behind TigerBeetle. It covers designing safer systems in less time through up-front design, assertions, and deterministic simulation.

Optiver's Carl Cook explains how to build high-frequency trading systems in C++, where the critical path runs rarely but must be extremely fast. He covers techniques for low and predictable latency, including avoiding main memory and cache misses.

Bryan Hunter's GigCityElixir 2023 talk on HCA Healthcare's Waterpark system, built on Elixir/Erlang. It describes how the architecture is distributed and fault-tolerant, with a multi-datacenter cluster and runtime code swapping.