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A VICE interview with Martin Shkreli about the 5000 percent price hike on a drug for AIDS-related infections and his role as the world's villain.

A Google I/O 2014 fireside chat in which members of the Android platform team answer questions about why the platform works the way it does. It is moderated by developer advocate Reto Meier.

Lex Fridman's long conversation with Elon Musk covering SpaceX, Mars, Tesla Autopilot and self-driving, robotics and AI.

JetBrains interviews Zig creator Andrew Kelley about why Zig has no 1.0 after a decade, why the project left GitHub, and why it bans AI contributions. He also covers what makes Zig better than C and his views on open source.

A BBC Politics Live interview in which Andrew Neil presses conservative commentator Ben Shapiro on his past statements and an incident involving Corey Lewandowski and a reporter. It is a tense, widely shared exchange.

Dwarkesh Patel interviews Andrej Karpathy on why reinforcement learning is flawed, why AGI may blend into steady GDP growth, why self-driving took so long, and the future of education. The conversation runs about two and a half hours.

Dr. Anthony Fauci joins the This Week in Virology podcast to discuss SARS-CoV-2 transmission, testing, immunity, vaccines and preparedness.

Excerpts from Nick Breeze's 2012 interview with researcher Natalia Shakhova about methane release from the East Siberian Arctic Shelf. She discusses the risk of abrupt methane emissions.

Rhonda Patrick interviews Dr. Bill Harris, co-inventor of the Omega-3 Index and author of more than 300 papers on fatty acids. They cover EPA and DHA dosing, fish oil studies such as REDUCE-IT, and how omega-3 levels relate to health and longevity.

A 2007 Computer History Museum conversation in which Nvidia CEO Jen-Hsun Huang interviews TSMC founder Morris Chang. Chang recounts his career and the creation of the dedicated silicon foundry model.

A 1996 BBC interview in which Noam Chomsky explains his propaganda model of the media to Andrew Marr, including how filters shape what journalists report and the role of self-censorship.

A roughly two and a half hour Noonautics panel on DMT research moderated by Graham Hancock with Andrew Gallimore and Rick Strassman. It discusses planned DMTx experiments and reported DMT experiences.

A Lex Fridman podcast conversation with Elon Musk focused on Tesla Autopilot, covering the motivation for Autopilot and Musk's views on self-driving safety and autonomy.

A three-minute clip of Noam Chomsky in an exchange with BBC journalist Andrew Marr about media filtering and self-censorship. Chomsky argues that people reach positions precisely because they would not say things that conflict with the system.

Rhonda Patrick interviews Salk Institute researcher Satchidananda Panda about circadian rhythms and the timing of food. They cover time-restricted feeding and its links to obesity, muscle mass, heart health, and light exposure.

Adam Neely interviews Damien Riehl and Noah Rubin about their project to generate and copyright every possible melody as MIDI. The video explains their reasoning and how it bears on music copyright lawsuits.

Fraser Cain interviews JPL physicist Slava Turyshev about using the Sun's gravity as a lens to image distant exoplanets. They cover how the lens works, how a spacecraft would align with it, and mission design.

Jim Coplien and Bob Martin debate test-driven development and unit testing in an InfoQ video that grew out of a JAOO 2007 dispute. They also touch on design and architecture.

Ross Douthat interviews Peter Thiel about technological stagnation, AI, longevity, space travel and politics. Thiel also lays out his framing of the Antichrist as a risk of civilizational stagnation.

A short clip of molecular biologist Cristina Sanchez describing her lab research on how THC affects cancer cells. It is uploaded on a channel promoting cannabis as a cancer treatment.

A short Channel NewsAsia interview clip in which MasterCard's Southeast Asia president voices distrust of cryptocurrencies produced by anonymous computers in anonymous places. It is part of the Perspectives series and runs about four minutes.

Kara Swisher and Walt Mossberg interview Elon Musk at Code Conference 2016 about one-way Mars missions, electric vehicles, autonomous cars, SpaceX booster reuse and AI.

A TechCrunch interview with Anthony Levandowski about his new startup Pronto.ai and autonomous vehicles, after the Uber and Waymo lawsuit. He discusses lessons learned and the role of lidar.

A long interview by Blender Guru with Ton Roosendaal, creator of Blender. They cover Blender's origins, the move to open source, why Ton is not driven by money, Autodesk, and what sets Blender apart from other open source projects.

Lex Fridman interviews legendary chip architect Jim Keller about Moore's Law, microprocessor design, and first-principles thinking. Keller draws on his work at AMD, Apple, Tesla and Intel, discussing instruction sets, transistor budgets, and self-driving.

Myst co-creator Rand Miller recounts how the HyperCard-built game struggled to run on 1x CD-ROM drives. He and his brother Robyn compressed image and audio data heavily to get acceptable performance. Part of Ars Technica's War Stories series.

Ezra Klein interviews Democratic pollster David Shor, who walks through survey data and charts explaining the 2024 election results. They discuss voter shifts, the education divide and what Democrats got wrong.

A short street interview from Invisible People with Keith, a homeless man in Los Angeles who lost his housing-industry job in the crash and moved from painkillers to heroin because it was cheaper. He talks candidly about the grip of addiction.

A fireside chat at LAUNCH Festival 2014 where Paul Graham tells Jason Calacanis why he is handing Y Combinator's presidency to Sam Altman. He also shares startup advice drawn from nine years and 500+ startups.

Yanis Varoufakis and Noam Chomsky talk on stage at the New York Public Library in 2016. They cover the Greek financial crisis, European politics, neoliberalism and America's economic future, drawing on Varoufakis's book.

The Centre for Computing History reunites Chris Curry, Steve Furber and Hermann Hauser to rewatch the BBC drama Micro Men on its tenth anniversary. They reminisce about Acorn and the early British home computer era.

A long interview with former KGB agent Yuri Bezmenov describing what he calls ideological subversion, a process of demoralizing a nation. He claims it works by influencing academia and media over years.

A clip of Yanis Varoufakis answering a question about China versus the EU on debt conditions. He contrasts Chinese non-interventionist lending with EU conditionality, drawing on the Piraeus port.

YC partner Michael Seibel discusses his essay on real product-market fit, why founders wrongly believe they have it, and how building a company is not a single-variable problem, drawing on Justin.tv and Socialcam.

A 13-minute clip from This Week in Startups in which Chamath Palihapitiya describes venture capital as a Ponzi-like scheme driven by fees and inflated valuations among VCs.

Chamath Palihapitiya's Stanford GSB View From The Top talk on money as an instrument of change. HN mostly knows it for his remarks on social media's dopamine-driven feedback loops and regrets about Facebook.

An excerpt of a C-SPAN interview in which Thomas Sowell argues that preferential admission policies produce mismatch, dropouts and resentment.

A clip from Lex Fridman's podcast in which chip architect Jim Keller argues that Moore's Law is not dead and that transistor scaling still has lots of room. He also discusses how to break down hard problems.

Stanford Blitzscaling class session where Reid Hoffman interviews Eric Schmidt about structuring teams and scaling Google. Topics include Alphabet, hiring, and how Chrome and Android operated inside the company.

Mike Acton, in a HandmadeCon 2015 interview with Casey Muratori, discusses game engine development, hiring and learning on your own.