practical effects

Rhonda Patrick of FoundMyFitness makes a case for isothiocyanates such as sulforaphane from cruciferous vegetables and broccoli sprouts. It covers cancer, aging, heart disease, brain and behavior, and neurodegeneration, with chapter timestamps.

Tom Wildenhain's guest lecture for CMU's Esoteric Programming Languages course shows that PowerPoint transitions and slides are Turing complete without macros, building up to a mind-bending fractal ending.

An 11-minute clip of Milton Friedman explaining the incentives of unions and how they affect employment. He argues unions restrict labor supply, raising pay for some workers while hurting low-skill workers.

Carnegie Mellon professor Randy Pausch gives a lecture on time management at the University of Virginia in 2007. He covers practical habits such as tackling important tasks first and distinguishing important from urgent work.

The final part of Dan Gelbart's 18-part Building Prototypes series, focused on mechanical design. It opens with a demonstration of stiffness and covers practical design principles for prototype machines.

Dr. Russell Barkley gives a nearly three-hour lecture of essential ideas about ADHD for parents, covering what ADHD is, its effects on executive function, motivation and emotion, and how it affects children.

A short excerpt from Dr Russell Barkley's 2012 Burnett Lecture on ADHD, focused on treatment. He argues ADHD is a disorder of executive function and self-regulation, and that environments should be designed to compensate.

James Mickens of Harvard gives a funny lecture at HBS's Future Assembly arguing that blockchains are a very bad idea. He covers their trust, legal and practical shortcomings for real-world problems.

Casey Muratori's University of Twente guest lecture is a case study in how straightforward code can cut thousands of lines and tens of seconds of runtime down to a few dozen lines running in under a second. It uses concrete examples to show why software is often an order of magnitude slower than it should be.

Robert Lustig of UCSF updates his sugar talk, arguing that fructose and processed foods drive obesity and metabolic syndrome through their endocrine effects. It is a roughly 90-minute university lecture.

Russell Barkley gives the keynote at UNC's 2012 Burnett Seminar on ADHD. He presents it as an executive function disorder and discusses its effects and how to help.

Y Combinator CEO Michael Seibel lectures at Startup School on building a product people want: identifying the problem, the customer, an MVP and which customers to pursue first.

Part 2 of a Q&A workshop with security researcher Jacob Appelbaum from April 2012, covering mobile phone security, cellphone forensics, state repression and surveillance. Topics include booting Tails from USB and surveillance self-defense resources.

Y Combinator partner Pete Koomen, who led Optimizely to $100M ARR, walks through the enterprise sales funnel. Chapters cover prospecting, outreach, qualification, pricing, closing, procurement and implementation.

Part 10 of Dan Gelbart's prototype-building lecture series, covering flexures: flexible joints that give precise, frictionless motion. It shows how a cheap piece of aluminum can become a nanometer-accurate mechanism.

Brian Kernighan gives a talk at the University of Nottingham on how to succeed in language design without really trying. He draws on his experience with awk and other languages.

A guest lecture Jon Gjengset gave at Two Sigma on using Rust for large, high-performance systems. It covers why Rust suits such projects, the Noria research database, a concurrent data structure used in it, and practical experience.

Tyler Bosmeny, CEO of Clever, gives a Y Combinator Startup School talk on how early-stage companies should approach sales and build an enterprise sales team.