aging

Veritasium presents David Sinclair's information theory of aging, which says aging is a loss of epigenetic information, and the evidence that aging can be slowed or reversed. It touches on stressors like fasting, exercise and cold exposure.

Rhonda Patrick of FoundMyFitness makes a case for isothiocyanates such as sulforaphane from cruciferous vegetables and broccoli sprouts. It covers cancer, aging, heart disease, brain and behavior, and neurodegeneration, with chapter timestamps.

Harvard geneticist David Sinclair discusses his book Lifespan at Google. He covers the biology of aging, lifestyle interventions and possible future ways to slow or reverse it.

Rick Reed of WhatsApp speaks at MeetBSD about running a messaging service on FreeBSD and Erlang at huge scale. He covers the stack, tuning and the challenges of millions of connections per host.

Robert Erdmann, a materials scientist at the Rijksmuseum, gives a PyCon keynote on the ultra-high-resolution imaging of Rembrandt's Night Watch. He covers the automated gantry camera system, the Python software that drives it, and the large volumes of image data involved.

A FOSDEM 2023 talk from the Matrix team on Matrix 2.0, covering sliding sync, the Element X client rewrite and next-generation calling. It explains how Matrix aims to match the speed of proprietary messengers.

Technology Connections explains how refrigerator and freezer design affects energy use, using chest freezers to show why top-opening designs and layout choices matter. It includes thermal-camera footage of cold air spilling out of upright units.

Explains the proposed NASA JPL plan to use the Sun as a gravitational lens, sending solar sail craft to its focal region to image an exoplanet's surface. It covers the distances involved, how imaging with the Sun would work and the mission design.

Kirk McKusick gives a narrative history of BSD from its start at UC Berkeley in the late 1970s through the 1980s releases and the lawsuit that led to 4.4BSD-Lite in 1992. It is full of anecdotes from a key developer.

Biochemist Nick Lane gives a Royal Institution lecture arguing that the Krebs cycle is central to what makes cells alive, not just genetic information. He draws on the themes of his book Transformer to link metabolism to the origin of life, death, and aging.

PBS Space Time explains the proposal to use the Sun's gravity as a giant lens, sending a train of small light-sail spacecraft to the focal point roughly 550 AU out. It covers how such a telescope could image exoplanets in surprising detail and the engineering challenges involved.

Charlie Marsh of Astral explains how uv, a Rust Python package manager, got so fast. He covers allocators, concurrency, zero-copy tricks and the challenges of Python packaging.

Moxie Marlinspike speaks at Next Generation Threats 2014 about the challenges of encrypted communication and how Signal addresses them. He also draws on American action movies as narrative for secure communications.

Marques Brownlee explains why iMessage's blue and green bubbles matter, covering the technical, commercial and social side of Apple's messaging lock-in. It also discusses RCS and what could be done about it.

Dave Jones of EEVblog tears down a 1991 IBM 9121 thermal conduction module from a System/390 mainframe, a 63-layer ceramic hybrid module with 2772 pins worth about $250,000, and demonstrates a BGA desoldering technique.

FreeBSD developer Benno Rice traces the history of init and bootstrap systems at linux.conf.au 2019 to explain why systemd was seen as necessary and why it provokes such strong reactions. He also discusses why change is scary.

Daniel Stone, a longtime X and Wayland developer, explains at linux.conf.au 2013 why X11's design became untenable and what motivated Wayland. The talk walks through X's history and accumulated cruft.

Dr. Jason Fung, a nephrologist, explains therapeutic fasting as a treatment for obesity and type 2 diabetes. He frames it around the two-compartment problem of fat storage and insulin resistance.

A Medlife Crisis video by cardiologist Rohin Francis on overdiagnosis and over-screening. It explains how detecting more disease does not necessarily mean saving more lives, and covers harms such as unnecessary treatment.

Dirk Hohndel explains why the Subsurface dive log project migrated from Gtk to Qt, the obstacles encountered, and advice for other applications frustrated with Gtk. It is a linux.conf.au 2014 talk.

Paul Turner of Google presents kernel interfaces for user-level scheduling of real threads, aiming at a uniform synchronous programming model across C++, Java, Go and Python. It introduces the switchto-style system calls behind Google's fibers.

3Blue1Brown builds toy SIR models to simulate how an epidemic spreads and tests scenarios like social distancing, travel restrictions, central gathering places and quarantine. It was made during the early COVID-19 outbreak.

Poul-Henning Kamp's FOSDEM 2014 talk is a hypothetical account of how an intelligence agency such as the NSA would sabotage open source software, standards and online discussion. It covers Skype's history, OpenSSL and psyops against standards.

X.Org developer Daniel Stone explains the history and technical limits of the X Window System and why Wayland was created, debunking myths from forum comments. He covers topics such as network transparency and blocking calls.

Ronald Minnich of Google explains how UEFI firmware is a large closed attack surface and describes Google's work replacing it with Linux-based boot firmware. It also touches on Intel ME and other security coprocessors.

Rob Landley compares Toybox and BusyBox and surveys options for embedded system command-line tools, including GNU. He also tells the story of leaving BusyBox, Toybox becoming Android's command line, and licensing.

Dr. Jason Fung, a nephrologist, presents his view of the causes of obesity and type 2 diabetes, focusing on hormones such as insulin rather than calories alone. The talk draws on research and his Intensive Dietary Management program.

Keith Packard traces the 35-year history of the X Window System at linux.conf.au 2020. He uses X to examine licensing, corporate interests and community dynamics in free software, including Unix workstation vendors and Stallman's influence.

Asian Boss interviews Professor Kim Woo-joo of Korea University Guro Hospital about COVID-19 in early 2020. He covers masks, testing, aerosol spread, and South Korea's response.

A lecture by Prof. Thomas Seyfried arguing that cancer is primarily a metabolic disease rather than a genetic one. It covers the Warburg effect, mitochondrial damage and implications for therapies.

Benno Rice's BSDCan 2018 talk on why systemd exists and what it got right and wrong. It traces the history of Unix init and why Linux distributions adopted it, while asking what the BSDs should learn.

A cardiologist runs a detailed, skeptical review of the Wim Hof Method, covering the research on cold exposure and breathing techniques. It also teaches how to read scientific statistics critically.

Science journalist potholer54 examines the claim that SARS-CoV-2 came from a Wuhan lab, tracing the sources behind it and the weaknesses in the evidence.

Dr. Howard Schubiner presents his research that much chronic pain comes from learned neural pathways rather than structural damage, and outlines a treatment approach based on that view.

Benno Rice's linux.conf.au 2020 talk asks whether UNIX was the best design we could have had. He looks at what alternatives existed, what was gained and lost, and what could be re-learned, including the limits of treating everything as a file.

Isaac Freund, author of the River Wayland compositor, talks about writing a Wayland compositor in Zig. He covers why he chose Zig over C and Rust and how Zig can wrap a hairy C library.

Jérôme Petazzoni explains how Linux containers are built from kernel features like cgroups, namespaces and SELinux. He demonstrates putting the pieces together by hand to make a container and compares runtimes and approaches like jails and zones.

Todd Becker's Ancestral Health Symposium talk arguing that myopia is driven by near-work and can be reversed, covering the biology and epidemiology and experimental evidence for reversal by using weaker lenses.

John Oliver's second Last Week Tonight segment on the opioid epidemic, covering the role of large companies in driving it. It touches on Purdue Pharma and the Sackler family.

A Ninja Nerd whiteboard lecture on the Moderna, Pfizer/BioNTech and AstraZeneca COVID-19 vaccines. It covers how each works, the preclinical and phase I-III trial process, and Operation Warp Speed.