dna replication

Destin of Smarter Every Day goes behind the scenes at the 23andMe lab to show how genotyping works. He also discusses DNA testing and privacy.

Veritasium explains how investigators caught the Golden State Killer using forensic genealogy, matching crime scene DNA to distant relatives in public genealogy databases. It also covers the privacy implications of DNA databases.

Veritasium explains why a large share of published research findings may be false, covering p-values, p-hacking, publication bias and low replication rates. It draws on John Ioannidis's well-known paper and describes reforms such as preregistration.

Geoff Cumming uses a simulation to show how wildly the p value varies from one replication to the next because of sampling variability. He argues for estimation and confidence intervals over null hypothesis significance testing.

Illumina's 3D animation of its sequencing-by-synthesis workflow, from sample preparation and cluster generation to sequencing on a flow cell and data analysis.

A short animation from the DNA Learning Center showing how mRNA carries a gene's message to the ribosome, where tRNA and codons are used to assemble amino acids into a protein.

Dr Brad Stanfield recounts the research history and scandal around resveratrol, the supposed anti-aging supplement, including problems with the original studies.