metabolism

Andrew Huberman interviews Harvard psychiatrist Chris Palmer about nutrition, metabolism and mental health, including the ketogenic diet as a treatment for depression and schizophrenia.

Robert Lustig of UCSF lectures on the biochemistry of sugar, arguing that fructose and lack of fiber drive the obesity epidemic via insulin. It is the widely viewed 90-minute talk that popularized the anti-sugar case.

A two-hour Huberman Lab podcast episode on the physiological effects of alcohol on the brain and body at different levels of consumption. It covers genetic predisposition to alcoholism, alcohol metabolism, and how it causes cellular stress and changes thinking and behavior.

Doug McGuff presents the biochemistry behind high-intensity strength training and the paleo diet, including how the body stores and burns fat. It is a roughly hour-and-a-half full-length lecture.

A short explainer on the physiological differences between fasting and simply eating less. It covers ketosis, ghrelin and hunger waves, and the hormonal effects of fasting.

Ruben Meerman presents a TEDx talk on the stoichiometry of weight loss, showing with lab demonstrations where fat goes when it is lost. He argues that most of it is exhaled as carbon dioxide.

A lecture by Prof. Thomas Seyfried arguing that cancer is primarily a metabolic disease rather than a genetic one. It covers the Warburg effect, mitochondrial damage and implications for therapies.

A long Huberman Lab podcast episode with Dr. Robert Lustig on the calories-in, calories-out model and how sugar, fructose, fiber and processed foods affect insulin, liver and metabolic health.

Kurzgesagt explains why exercise alone does little for weight loss, since the body compensates by adjusting its total energy expenditure. It argues exercise is still very valuable for health.

Stanford Health Care hosts Christopher Gardner and Robert Lustig on whether all calories are equal, with a focus on processed food and sugar. The talk questions the idea that calories in versus calories out fully explains weight and health.

Neurologist Dr. Matthew Phillips talks at Low Carb Gold Coast 2022 about fasting and ketogenic diets as therapies for cancer and neurodegenerative disease. He focuses on mitochondrial dysfunction and brain energy metabolism.

Rhonda Patrick gives an IHMC talk on how genetic variation affects micronutrient absorption and metabolism, and how diet changes gene expression. It also covers epigenetics, including heritable changes, and stress tolerance.

Physicist Geoffrey West speaks at an FQXi conference on time about complexity and scaling laws. He covers how metabolism, growth and lifespan scale across organisms and how the same mathematics applies to cities and companies.

Biochemist Nick Lane gives a Royal Institution lecture arguing that the Krebs cycle is central to what makes cells alive, not just genetic information. He draws on the themes of his book Transformer to link metabolism to the origin of life, death, and aging.

Dr. Michael Greger presents his book How Not to Die at Google NYC, arguing that diet and lifestyle changes can prevent or reverse many of the top causes of death. He walks through evidence on whole-food plant-based eating.

Joseph Everett, with Dr. Frank Mitloehner, argues that eating less meat will not do much for the climate. He covers beef's water footprint, land and feed use, and methane.

Dr. Jason Fung, a nephrologist, explains therapeutic fasting as a treatment for obesity and type 2 diabetes. He frames it around the two-compartment problem of fat storage and insulin resistance.

Dr. Terry Wahls tells how she used diet to manage her multiple sclerosis and get out of a wheelchair, drawing on mitochondrial biology. TED flagged the talk as health advice based on personal narrative.

Nina Teicholz, author of The Big Fat Surprise, speaks at Low Carb Gold Coast 2017 about the history and health implications of vegetable and seed oils. She covers the political and institutional forces behind dietary fat advice.

Psychologist Melanie Joy's TEDxMunchen talk introduces carnism, the invisible belief system that conditions people to eat some animals but not others, and how it shapes reactions to food choices.

Gary Taubes presents the argument of his book Why We Get Fat to Googlers in 2011. He claims the type of calories matters more than the count, challenges calories-in-calories-out thinking and criticizes the low-fat dietary consensus.

Cardiologist Dr. Pradip Jamnadas lectures on the rationale for dietary restriction and fasting, covering insulin resistance, glucose intolerance, and low-carb eating over about 81 minutes.

Dr. Sarah Hallberg argues in a TEDx talk that type 2 diabetes can be treated and potentially reversed through diet, especially by restricting carbohydrates. TED flagged the talk as outside its guidelines and warned against taking it as medical advice.

Adam Ragusea examines whether olive oil is unsafe for high-heat cooking and whether it tastes bad when heated. He cites studies showing it is among the most stable cooking oils and that smoke-point worries are overblown.

Mark Rober makes a plant-based burger for Bill Gates and explains why meat production strains the environment. Gates also appears and discusses his worry about steel and cement.

Robert Lustig of UCSF updates his sugar talk, arguing that fructose and processed foods drive obesity and metabolic syndrome through their endocrine effects. It is a roughly 90-minute university lecture.

A What I've Learned video arguing that industrial seed and vegetable oils have displaced saturated fats and harmed health. It covers the history of vegetable oils, the American Heart Association's role, and rising consumption.

Rhonda Patrick interviews Salk Institute researcher Satchidananda Panda about circadian rhythms and the timing of food. They cover time-restricted feeding and its links to obesity, muscle mass, heart health, and light exposure.

Dr. Jason Fung, a nephrologist, presents his view of the causes of obesity and type 2 diabetes, focusing on hormones such as insulin rather than calories alone. The talk draws on research and his Intensive Dietary Management program.

A short Healthcare Triage episode by Aaron Carroll arguing that milk gets an undeserved pass in efforts to improve diets. It examines claims about calcium and bone strength and concludes you don't need to drink milk.

Rhonda Patrick interviews Dr. Bill Harris, co-inventor of the Omega-3 Index and author of more than 300 papers on fatty acids. They cover EPA and DHA dosing, fish oil studies such as REDUCE-IT, and how omega-3 levels relate to health and longevity.

Joseph Everett argues, drawing on the book The Salt Fix, that most people benefit from more rather than less salt, and reviews studies on sodium, potassium and blood pressure.

Rhonda Patrick interviews USC gerontologist Valter Longo about fasting, the fasting-mimicking diet, and their effects on longevity, cancer, and multiple sclerosis. They discuss mechanisms such as IGF-1 and autophagy and clinical trials.

A Huberman Lab podcast episode on the gut-brain axis and how the gut microbiome affects the nervous system, hunger and overall health. It covers the pathways by which the gut influences the brain and practical steps for gut health.

A presentation by Janice Stanger arguing that protein is overhyped and that excess or the wrong kinds of protein are harmful. It promotes a whole-foods, plant-based diet.

Ophthalmologist Chris Knobbe argues that excess omega-6 seed oils are a unifying cause of chronic diseases of civilization such as diabetes and macular degeneration. He presents the case at Low Carb Denver 2020.

Dr. Jason Fung lectures on why obesity became an epidemic since the 1970s, arguing insulin and hormones rather than calories drive weight gain. He explains why calorie counting fails and touches on low-carb eating and fasting.

Ivor Cummins gives an 82-minute presentation on the history and science of vitamin D and human health. He draws on expert interviews to argue that sun exposure and vitamin D status are linked to many chronic diseases.

Rhonda Patrick of FoundMyFitness makes a case for isothiocyanates such as sulforaphane from cruciferous vegetables and broccoli sprouts. It covers cancer, aging, heart disease, brain and behavior, and neurodegeneration, with chapter timestamps.

Dr. Jason Fung's talk at the 2018 CrossFit Health Conference on therapeutic fasting for weight loss. He explains why long-term weight loss is hard and tackles common myths.